PROFHILO® STRUCTURA

PROFHILO® STRUCTURA – Key Features and Benefits

PROFHILO® STRUCTURA is an injectable treatment specifically designed to restore facial structure by regenerating superficial fat layers. It repositions tissue lost to aging or weight loss, delivering a natural lift without the volumizing effect of traditional fillers.

• Targets superficial fat compartments for structural rejuvenation

• Uses patented NAHYCO® technology (no chemical cross-linkers)

• Contains 90 mg of ultrapure hyaluronic acid (45 mg H-HA + 45 mg L-HA per 2 mL syringe)

• Clinically shown to improve midface contours in 95% of patients

• Enhances skin texture, firmness, and hydration without altering identity

• Non-volumizing, natural-looking results with minimal downtime

• Effective in reversing facial changes caused by Ozempic-induced fat loss

PROFHILO® STRUCTURA – Indications

PROFHILO® STRUCTURA is indicated for facial treatment and adipose tissue restoration, especially in patients experiencing age-related or medication-induced fat loss.

• Rejuvenation of the midface, including:

  • Hollows and sagging in the cheeks

  • Loss of projection and facial angle flattening

• Suitable for:

  • “Sinkers” – patients with hollow facial features due to adipose depletion

  • “Saggers” – patients with tissue descent and fat bulging

• Also beneficial post-semaglutide (Ozempic) fat loss

• Used to treat zygomatic and peri-orbital regions, jawline, and marionette lines

PROFHILO® STRUCTURA – Ingredients

PROFHILO® STRUCTURA is formulated using ultrapure hyaluronic acid, stabilized via thermal bonding without chemical agents.

• Active ingredients:

  • 45 mg high molecular weight hyaluronic acid (H-HA) – 1100–1400 kDa

  • 45 mg low molecular weight hyaluronic acid (L-HA) – 80–100 kDa

• Total: 90 mg of HA per 2 mL syringe

• Stabilized Hybrid Cooperative Complexes (HCC) using NAHYCO® technology

• No chemical cross-linkers or foreign body reaction

PROFHILO® STRUCTURA – How To Use

PROFHILO® STRUCTURA is administered via cannula injection into the subcutaneous fat layer, not the dermis. The treatment protocol includes two sessions spaced one month apart.

• Injection area: Preauricular midface (upper cheek)

• Depth: Subcutaneous layer (superficial fat layer)

• Frequency: Two treatments, 30 days apart

• Tools provided:

  • TSK cannula 22Gx50mm and 25Gx38mm

  • TSK pilot needles 21Gx25mm and 23Gx19mm

• Volume: 2 mL per syringe (single-use)

• Advantages of cannula:

  • 77.1% reduction in vascular occlusion risk compared to needle

PROFHILO® STRUCTURA – Side Effects

In clinical evaluations, no adverse reactions were reported. The treatment is considered highly tolerable with excellent safety.

• Mild, temporary effects may include:

  • Redness

  • Swelling

  • Bruising at injection site

• Serious complications (e.g., vascular occlusion) are rare and reduced with cannula use

• Not recommended during pregnancy or breastfeeding

PROFHILO® STRUCTURA – Clinical Studies

Clinical studies show that PROFHILO® STRUCTURA is effective in increasing tissue thickness and restoring fat in aging or volume-depleted faces.

• 95% of patients reported visible improvement after the first session

• Results sustained 3 months after treatment

• +23% increase in tissue thickness, statistically significant (p<0.05)

• Improvements noted in:

  • Zygomatic and peri-orbital area

  • Lower third of face (jawline, marionette lines)

• No patients reported adverse events in the 22-subject clinical trial

PROFHILO® STRUCTURA – Manufacturer Information

PROFHILO® STRUCTURA is developed by IBSA Derma, a division of IBSA Group, a Swiss-based pharmaceutical company with global operations.

• Manufacturer: IBSA Farmaceutici Italia S.r.l., Lodi, Italy

• Parent company: IBSA Group, founded in 1945

• Global presence:

  • Products in 80+ countries

  • 25+ offices and manufacturing sites

• Specializes in ultrapure hyaluronic acid technologies

• Controls entire production chain, including biofermentation and final packaging

PROFHILO® STRUCTURA – FAQ

What is PROFHILO® STRUCTURA used for?
It’s used for midface rejuvenation by restoring superficial facial fat lost due to aging or weight loss (including Ozempic-induced).

Is PROFHILO® STRUCTURA a filler?
No. Unlike fillers, it does not volumize tissue but restores fat through regenerative biostimulation.

How is it different from regular Profhilo®?
Profhilo® is injected in the dermis for skin improvement, while Structura targets fat tissue, producing a lifting and contouring effect.

How many treatments are needed?
Two treatments spaced one month apart are standard.

How long do results last?
Improvements are visible after the first session and are maintained for at least 3 months; longer results are reported anecdotally.

Is there downtime?
No significant downtime. Patients can resume normal activities the same day.

Is it safe?
Yes. Clinical studies report no adverse effects, and cannula injection reduces risk of vascular complications by 77.1%.